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KMID : 0617819960060010238
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Journal of Wonkwang Oriental Medicine
1996 Volume.6 No. 1 p.238 ~ p.256
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Antitoxic effects of Rhizoma Smilacis Glabrae against Cadmium Toxicity in Rats
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Abstract
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A study on the antitoxic effects of Rhizoma Smilacis Glabrae extracts against Cadmium Chloride Toxicity in Rats.
This study was performed to find out the effect of rhizoma smilacis glabrae against Cadmium toxicity.
The experimental rats were divided into 5 groups such as control group, Cadmium alone treatment group, three simultaneous treatment groups of rhizoma smilacis glabrae and cadmium. Rat were given pellets administration with three dosage of rhizoma smilacis glabrae such as 4mg/kg body weight for two weeks.
The results were summarized as follows:
1. The simultaneously administration of rhizoma smilacis glabrae and cadmium concentration in liver tissue compared to the administration of cadmium alone.(p〈0.05)
2. The simultaneously administration of rhizoma smilacis glabrae and cadmium significantly more increased metallothionein concentration in liver and Kidney tissues compared to administration alone(p〈0.05)
3. When liver and kidney tissues were observed with optical microscope obvious changes were visible in those tissues.
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